Differential Classical Conditioning of the Gill-Withdrawal Reflex in Aplysia Recruits Both NMDA Receptor-Dependent Enhancement and NMDA Receptor-Dependent Depression of the Reflex
نویسندگان
چکیده
منابع مشابه
Differential classical conditioning of the gill-withdrawal reflex in Aplysia recruits both NMDA receptor-dependent enhancement and NMDA receptor-dependent depression of the reflex.
Differential classical conditioning of the gill-withdrawal response (GWR) in Aplysia can be elicited by training in which a conditioned stimulus (CS) delivered to one side of the siphon (the CS+) is paired with a noxious unconditioned stimulus (US; tail shock), while a second conditioned stimulus (the CS-), delivered to a different siphon site, is unpaired with the US. NMDA receptor (NMDAR) act...
متن کاملClassical conditioning in a simple withdrawal reflex in Aplysia californica.
The ability of Aplysia and other gastropod molluscs to exhibit complex behaviors that can be modified by associative learning has encouraged us to search for an elementary behavior controlled by a simple and well analyzed neural circuit that also can be modified by this type of learning. Toward that end, we have now produced classical conditioning in the defensive siphon and gill withdrawal ref...
متن کاملHabituation and dishabituation of the gill-withdrawal reflex in Aplysia.
A behavioral reflex mediated by identified motor neurons in the abdominal ganglion of Aplysia undergoes two simple forms of shortterm modification. When the gill-with-drawal reflex was repeatedly evoked by a tactile stimulus to the siphon or mantle shelf, the amplitude of the response showed marked decrement (habituation). After a period of rest the response showed spontaneous recovery. The amp...
متن کاملDifferential classical conditioning of a defensive withdrawal reflex in Aplysia californica.
The defensive siphon and gill withdrawal reflex of Aplysia is a simple reflex mediated by a well-defined neural circuit. This reflex exhibits classical conditioning when a weak tactile stimulus to the siphon is used as a conditioned stimulus and a strong shock to the tail is used as an unconditioned stimulus. The siphon withdrawal component of this reflex can be differentially conditioned when ...
متن کاملA quantal analysis of the synaptic depression underlying habituation of the gill-withdrawal reflex in Aplysia.
Habituation, one of the simplest behavioral paradigms for studying memory, has recently been examined on the cellular level in the gill-withdrawal reflex in the mollusc Aplysia and in the escape response in cray-fish. In both cases short-term habituation involved a decrease in excitatory synaptic transmission at the synapses between the sensory neurons and their central target cells. To analyze...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2581-06.2007